Material Safety Data Sheet (MSDS)
Vitamin B2 (Riboflavin) flowing particle

Section 1 : Chemical Product and Company Identification

Section 2 : Composition and Information on Ingredients

Section 3 : Hazards Identification

Potential Acute Health Effects :
Hazardous in case of ingestion. Slightly hazardous in case of skin contact (irritant), of eye contact (irritant), of inhalation.
Potential Chronic Health Effects :
CARCINOGENIC EFFECTS: Not available.
MUTAGENIC EFFECTS: Not available.
TERATOGENIC EFFECTS: Not available.
DEVELOPMENTAL TOXICITY: Not available.
Repeated or prolonged exposure is not known to aggravate medical condition.

Section 4 : First Aid Measures

Eye Contact : Immediately flush eyes with running water for 15 minutes, keeping eyelids open.
Skin Contact : After contact with skin, wash immediately with plenty of water. Gently and thoroughly wash the contaminated skin. Cover the irritated skin with an emollient. If irritation persists, seek medical attention. Wash contaminated clothing before reusing.
Serious Skin Contact : Not available.
Inhalation : Allow the victim to rest in a well ventilated area. Seek immediate medical attention.
Serious Inhalation : Not available.

Section 5 : Fire and Explosion Data

Flammability of  Product : May be combustible at high temperature.
Auto-Ignition Temperature :  Not available.
Flash Points : Not available.
Flammable Limits : Not available.
Products of Combustion : These products are carbon oxides (CO, CO2), nitrogen oxides (NO, NO2.).
Explosion Hazards in Presence of Various Substances:
Risks of explosion of the product in presence of mechanical impact : Not available.
Risks of explosion of the product in presence of static discharge : Not available.
Fire Fighting Media and Instructions:
SMALL FIRE : Use DRY chemical powder.
LARGE FIRE : Use water spray, fog or foam.
Special Remarks on Fire Hazards : Not available.
Special Remarks on Explosion Hazards : Not available.

Section 6 : Accidental Release Measures

Methods for cleaning up : collect solids(avoid dust formation) and hand over to waste removal; rinse with plenty of water

Section 7 : Handing and Storage

Handling
Technical measures : avoid dust formation; high dust explosion hazard; take precautionary measures against electrostatic charging; protected from light; processing in closed systems, superposed by inert gas (e.g.nitrogen)
Suitable materials : stainless steel, aluminium, enamel, glass
Storage
Storage conditions : protected from light
Validity : 36 months, < 25 °C, in the unopened original container, see "best use before" date stated on the label, after opening the container, the contents should be used within a short period
Packaging materials : impervious to light ; tightly closing; material: aluminium, food-approved plastics

Section 8 Exposure controls/Personal protection

Monitoring
Threshold value (Roche) air - IOEL: 4 mg/m3 (Internal Occupational Exposure Limit, defined as 8-hour time-weighted average)
Analytics : sampling on glass fibre filter and gravimetric or chemical determination
Personal protective equipment
Respiratory protection : respiratory protection not necessary during normal operations
Hand protection : protective gloves
Eye protection : safety glasses

Section 9 Physical and chemical properties

Colour : orange-brown to yellow-brown
Form : free-flowing particle
Bulk density : 0.5 kg/L
Sieve analysis : ≤5 % through USP standard sieve no. 270 (Ø 53 μm)
Solubility : insoluble for practical purposes, water

Section 10 Stability and reactivity

Stability : stable under the conditions mentioned in section 7
Conditions to avoid : light
Materials to avoid : reducing agents, choline chloride

Section 11 Toxicological information

Acute toxicity :  LD50 > 2000 mg/kg (oral, mouse)
                           LD50 > 10000 mg/kg (oral, rat)
                           LD50  50 mg/kg (i.v., rat)
                           LD50  365 mg/kg (i.v., mouse)
                           LD50  560 mg/kg (i.p., rat)
                           LD50  5000 mg/kg (s.c., rat)
                           LD50  340 mg/kg (i.p., mouse)
Sensitization : very rare cases of sensitisation possible (man)
Chronic toxicity : low toxicity (man); hypervitaminosis B2 is unknown
Mutagenicity : not mutagenic (various in vivo and in vitro test systems)
Reproduction toxicity : not teratogenic, not embryotoxic (rat)
Note — therapeutic dose (in deficiency conditions): 5-10 (to 100) mg/day
large doses result in a bright yellow discolouration of the urine
ADI (acceptable daily intake) : 0.5 mg/kg/day

Section 12 Ecological information

Ready biodegradability : readily biodegradable 100 %, 28 days (Manometric Respirometry Test, OECD No. 301 F)
Ecotoxicity :
— barely toxic for planktonic crustaceans (Daphnia magna)
EC50 (48 h) > 47.4 mg/L  (OECD No. 202) *1
— barely toxic for fish (rainbow trout)
LC0 (96 h) > 500 mg/L  (OECD No. 203) *1
— moderately toxic for algae (Scenedesmus subspicatus)
ErC50 (72 h) 21 mg/l
EbC50 (72 h) 9.8 mg/l
NOErC (72 h) 7.3 mg/l
(OECD No. 201)
— barely toxic for microorganisms (activated sludge)
NOEC (28 d)≥100 mg/l
(Manometric Respirometry Test, OECD No. 301 F)
Note — starch is not toxic for fish

Section 13 Disposal considerations

Waste from residues : observe local/national regulations regarding waste disposal

Section 14 Transport Information

Not classified by transport regulations

Section 15 Regulatory information

No classification and labelling according to EU directives
Water hazard class (Germany) : weakly hazardous for water

Section 16 Other information

Use : for animal nutrition (premixes, compound feeds)
Biological activity : no biological activity has been defined for vitamin B2